Morphological and functional changes in guinea-pig neurons projecting to the ileal mucosa at early stages after inflammatory damage

Abstract

Non-technical summary: Inflammation in the gut causes changes in neurons that control its movement and secretion. This leads to symptoms of pain and functional disorders that may persist long after the resolution of inflammation, which in humans manifests as the irritable bowel syndrome. In this study we demonstrate an association between hyperexcitability of neurons in the gut wall, damage to the nerve terminals in the mucosa and inflammation close to neurons and their terminals. These results increase our understanding of the triggering mechanisms that contribute to post-inflammatory gut dysfunctions.Abstract In the present study the relationship between tissue damage and changed electroph..